Christina Chan


Selected Publications

Reviewed Journal Publications

Bansal, M.; NCI DREAM Community; et al. “Predicting activity of drug combinations through crowdsourcing”, (2014) Nature Biotechnology, In review, (2014).

Fang, L.; Cho, H.J.; Chan, C.; Feig, M. “Binding site multiplicity with fatty acid ligands: Implications for the regulation of PKR kinase autophosphorylation with palmitate” Proteins, In review, (2014) .

Costello, C.; NCI DREAM Community; et al. “The challenge of drug sensitivity prediction: an assessment of methods through collaborative competition”, Nature Biotechnology, In press, (2014).

Hejase, H. A.; Chan, C. “Improving Drug Sensitivity Prediction Using Different Types of Data”, CPT: Pharmacometrics & Systems Pharmacology, In press, (2014).

Liu, C.; Baek, S.; Kim, J.; Vasko, E.; Chan, C. “Effect of Static Pre-stretch Induced Surface Anisotropy on Orientation of Mesenchymal Stem Cells”, Cellular and Molecular Bioengineering, 7(1), 106-121, (2014). (PMC3963186)

Liu, L.; Chan, C. “IPAF inflammasome in astrocyte enhances neurotoxicity, a novel target for Alzheimer's disease”, Neurobiology of Aging, 35; 309-321, (2014). (PMC3832124)

Malefyt, A.; Wu, M.; Vocelle, D.; Kappes, S.; Lindeman, S.; Chan, C.; Walton, S. P. “Improved asymmetry prediction for siRNAs”, FEB Journal, 281(1), 320-30, (2014). (PMC3924726).

Liu, L.; Chan, C. “The role of inflammasome in Alzheimer’s disease”, Ageing Research Reviews, 15, 6–15, (2014).

Wu, M.; Chan, C. “Prediction of Therapeutic microRNA based on the Human Metabolic Network”, Bioinformatics, 30(8), 1163-1171, (2014).

Huang, C.; Wu, M.; Liu, D.; Chan, C. “A mathematical model of MAPK and PKR-IRS pathways in insulin signaling”, Journal of Theoretical Biology, 355, 40-52, (2014).

Hijazi, H.; Chan, C. “A Classification Framework Applied to Cancer Gene Expression Profiles”, special issue on Engineering in Cancer Treatment, Journal of Healthcare Engineering, 4(2), 255–283, (2013).

Geekiyanage, H.;Upadhye, A.; Chan, C. “Inhibition of serine palmitoyltransferase reduces amyloid-β and tau hyperphosphorylation in a mouse model, a safe therapeutic strategy for Alzheimer’sdisease”, Neurobiology of Aging, 34, 2037-2051, (2013).

Pan, X.; Whitten, D. A.; Wu, M.; Chan, C.; Wilkerson, C. G.; Pestka, J. J. “Global Protein Phosphorylation Dynamics during Deoxynivalenol-Induced Ribotoxic Stress Response in the Macrophage”, Toxicology and Applied Pharmacology 268(2), 201–211, (2013). doi:10.1016/j.taap.2013.01.007

Angart, P.; Vocelle, D.; Chan, C.; Walton, S. P. “Design of siRNA Therapeutics from the Molecular Scale”, Pharmaceuticals, 6, 440-468, (2013). (PMC3749788)

Wu, M.; Liu, L.; Hijazi, H.; Chan, C. “A multi-layer inference to reconstruct condition-specific genes and their regulation”, Bioinformatics, 29(12), 1541-1552, (2013). doi: 10.1093/bioinformatics/btt186. (PMC3673221)

Patil, S.; Tran, N.; Geekiyanage, H.; Chan, C. “Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons”, Neuroscience Letters, 554, 121– 125, (2013). (PMC3825752)

Liu, L.; Martin, R.; Kohler, G.; Chan, C. “Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes”, Experimental Neurology, 248, 482–490, (2013). (PMC3787872)

Bilgin, B.; Liu, L.; Chan, C.; Walton S. P. “Quantitative, solution-phase profiling of multiple transcription factors in parallel”, Analytical and Bioanalytical Chemistry, 405(8), 2461-8, (2013).

Pan, X.; Whitten, D. A.; Wu, M.; Chan, C.; Wilkerson, C. G.; Pestka, J. J. “Early Phosphoproteomic Changes in the Mouse Spleen During Deoxynivalenol-Induced Ribotoxic Stress”, Toxicological Science, 135(1), 129-143, (2013).

Lyman, D.; Peterson, C.; Maloney, R.; Shahriari, D.; Garris, A.; Saleh, S.; Mehrotra, S.; Chan, C.; Sakamoto, J. “Augmenting Protein Release from Layer- by-Layer Functionalized Agarose Hydrogels”, Carbohydrate Polymers, 103, 377–384, (2013).

Li, L.; Martin, R.; Chan, C. “Palmitate-activated Astrocytes via SPT Increases BACE1 in Primary Neurons by SMases,” Neurobiology of Aging 34, 540-550, (2012).

Mehrotra, S.; Lynam, D.; Liu, C.; Shahriari, D., Lee, I.; Tuszynski, M.; Sakamoto, J.; Chan, C. “Time Controlled Release of Arabino-furanosylcytosine (Ara-C) from Agarose Hydrogels using Layer-By-Layer Assembly: An In-vitro Study,” Journal of Biomaterials Science, Polymer Edition, 23, 439–463, (2012).

Maleyt, A.; Walton, S.P.; Chan, C. “Analysis of Endocytosis Pathways for Nucleic Acid Therapeutics,” NanoLife 2(3), 1-9, (2012).

Wu, M.; Chan, C. “Learning Transcriptional Regulation on a Genome Scale: a Theoretical Analysis Based on Gene Expression Data,” Briefings in Bioinformatics 13(2), 150-161, (2012).

Geekiyanage, H.; Jicha, G.; Nelson, P.; Chan, C. “Blood Serum miRNA: Non-invasive Biomarkers for Alzheimer’s Disease,” Experimental Neurology 235, 491–496, (2012).

Wu, M.; Chan, C. “Human Metabolic Network: Reconstruction, Simulation, and Applications in Systems Biology,” Metabolites 2, 242-253, (2012).

Cho, H.; Wu, M.; Bilgin, B.; Walton, S.P.; Chan, C “Latest Developments in Experimental and Computational Approaches to Characterize Protein-Lipid Interactions,” Proteomics 12(22), 3273-3285, (2012).

Cho, H.; Chan, C. “IRE1 Transmembrane Domain in SDS,” Biochemical and Biophysical Research Communications 427(4), 764–767, (2012).

Hijazi, H.; Wu, M.; Nath, A.; Chan, C. “Ensemble Classification of Cancer Types and Biomarker Identification,” Drug Development Research 73(7), 414-419, (2012).

Cho, H.; Wu, M.; Zhang, L.; Thompson, R.; Nath, A.; Chan, C. “Palmitate-induced Dysregulation of ER-related Stress Responses in HepG2 Cells Mediated by ATF4 and CREB”, BMC Systems Biology 7, 9, (2012).

Wang, X.; Nath, A.; Yang, X.; Portis, A.M.; Walton, S.P.; Chan, C. "Synergy Analysis Reveals Association between Insulin Signaling and Desmoplakin Expression in Palmitate Treated HepG2 Cells," PLoS ONE, 6(11): e28138, (2011). Link

Zhang, L.; Seitz, L. C.; Abramczyk, A. M.; Liu, Li; Chan, C. “cAMP initiates early-phase neuron-like morphological changes and late-phase neural differentiation and function in mesenchymal stem cells”, Cellular and Molecular Life Sciences, 68(5), 863-876, (2011).

Cho, H.; Mukherjee, S.; Palasuberniuam, P.; Pillow, L. ; Bilgin, B.; Nezich, C.; Walton, S.P.; Feig, M.; Chan, C. "Molecular Mechanism by which palmitate inhibits PKR autophosphorylation." Biochemistry. 50:1110-1119, (2011).

Mehrotra, S.; Liu, C.; Lee, I.; Chan, C. “Polyelectrolyte multilayer stamping in aqueous phase and non-contact mode,” Industrial & Engineering Chemistry Research, 50 (15), 8851–8858, (2011) .

Geekiyanage, H.; Chan, C. “MicroRNA-137/181c regulate serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer’s disease”, Journal of Neuroscience, 31(41), 14820 –14830, (2011).

Wu, M.; Chan, C. “Identification of novel targets for breast cancer by exploring gene switches on a genome scale”, BMC Genomics, 12, 547, (2011).

Walton, S.P., Wu, M., Gredell, J.A., and Chan, C. Designing highly active siRNAs for therapeutic applications. FEBS J. 277:4806–4813, (2010).

Dalkic, E., Wang, X., Wright, N. T., and Chan, C. “Cancer-Drug Associations: A Complex System”, PlosOne, 5(4) e10031, (2010). (PMCID: PMC2848862)

Yang, X.; Nath, A.; Opperman, M. J.; and Chan, C. “PKR differentially regulates IRS1 and IRS2 in HepG2 cells”, Molecular Biology of the Cell, 21, 3449–3458, (2010) .

Zhang, L.; Chan, C. “Isolation and Enrichment of Rat Mesenchymal Stem Cells (MSCs) and Separation of Single-colony Derived MSCs”, Journal of Visualized Experiments, 37 (2010).

Mehrotra, S.; Hunley, G.; Pawelec, K.M.; Zhang, L.; Lee, I.; Baek, S; Chan, C. “Cell Adhesive Behavior on Thin Polyelectrolyte Multilayers: Cells Attempt to Achieve Homeostasis of its Adhesion Energy,“ Langmuir 26, 12794-12802, (2010).

Patil, S. P., Maki, S., Khedkar, S. A., Rigby, A. C. and Chan, C., “Withanolide-A and asiatic acid modulate multiple targets associated with AβPP processing and Aβ clearance”, Journal of Natural Products, 73: 1196-1202, (2010).

Gredell, J. A., Dittmer, M. J., Wu, M., Chan, C. and Walton, S. P. Recognition of siRNA Asymmetry by TAR RNA Binding Protein, Biochemistry, in press, (2010).

Zhang, L., Seitz, L. C., Abramczyk, A. M., and Chan, C. “Synergistic effect of cAMP and palmitate in promoting altered mitochondria function and cell death in HepG2 cells”, Experimental Cell Research, 316: 716-727, (2010). (PMCID: PMC2826503)

Mehrotra, S.; Lynam, D.; Maloney, R.; Pawelec, K. M.; Tuszynski, M.; Lee, I.; Chan, C.; Sakamoto, J. "Time controlled protein release from layer-by- layer assembled multilayer functionalized agarose hydrogels." Advanced Functional Materials 20, 247-258 (2010).

Portis, A. M.; Carballo, G.; Baker, G. L.; Chan, C.; Walton, S. P. “Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles”, Microscopy Research and Technique, 73, 878–885, (2010).

Yang, X.; Chan, C. “Repression of PKR Mediates Palmitate-Induced Apoptosis in HepG2 Cells through Bcl-2”, Cell Research, 19(4), 469-486, (2009) .

Dalkic, E.; Nash, D. E. W.; Fassia, M. K.; and Chan, C. “Integrative Analysis of Cancer Pathway Progression”, Proteomics – Clinical Applications, 3, 473-85, (2009).

Leekumjorna, S.; Cho, H. J.; Wu, Y.; Wright, N. T.; Sum, A. K.; Chan, C. "Fatty Acid Induced Toxicity: The Role of Saturation in Degrading and Benefiting Cell Survival", Biochimica et Biophysica Acta - Biomembranes, 1788, 1508-1516, (2009).

Mehrotra, S.; Lee, I.; Chan, C. "Multilayer Mediated Forward Patterned siRNA Transfection using Linear-PEI at Extended N/P Ratios," Acta Biomaterialia, 5, 1474–1488, (2009).

Yang, X.; Zhou, Y.; Jin, R.; Chan, C., “Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization”, Bioinformatics, 25(17), 2236–2243, (2009).

Wu, M., Yang, X., and Chan, C., “A dynamic analysis of insulin signaling and its feedback mechanisms: A discrete modeling approach”, PLoS ONE, i4(120: e8040(1-12). (PMCID: PMC2779448) (2009).

Srivastava, S. and Chan, C., “Application of Metabolic Flux Analysis to Identify the Mechanisms of Free Fatty Acid Toxicity to Human Hepatoma Cell Line, HepG2”, Biotechnology and Bioengineering 99: 399–410, (2008).

Kidambi, S.; Lee, I.; Chan, C. "Patterned Co-culture of Neurons and Astrocytes on Polyelectrolyte Multilayer Films for Studying Astrocyte Mediated Oxidative Stress in Neurons," Advanced Functional Materials 18(2), 294 - 301, (2008).

Kidambi, S.; Chan, C.; Lee, I. "Tunable Resistive m-dPEG Acid Patterns on Polyelectrolyte Multilayers at Physiological Condition for Directed Deposition of Multiple Biomacromolecules," Langmuir 24(1), 224 -230, (2008).

Li, Z.; Srivastava, S.; Findlan, R.; Chan, C. “Using dynamic gene module map analysis to identify targets that modulate free fatty acid and tumor necrosis factor (TNF)-α induced cytotoxicity,” Biotechnology Progress, 24(1), 29-37, (2008).

Jin, R.; Si, L.; Chan, C. “A Bayesian Framework for Knowledge Driven Regression Model in Micro-array Data Analysis,” International Journal of Data Mining and Bioinformatics (IJDMB), 2(3): 250-267 (2008).

Patil, S.; Balu, D.; Melrose, J.; Chan, C. “Brain region specificity of palmitic acid-induced Alzheimer-like changes in primary neurons”, BMC Research Notes, June 4; 1(1):20, (2008).

Leekumjorn, S.; Wu, Y.; Sum, A.K.; and Chan, C. “Experimental and Computational Studies Investigating Trehalose Protection of HepG2 Cells from Palmitate Induced Cytotoxicity”, Biophysical Journal, 94, 1-15, (2008).

Srivastava, S., Zhang, L., Jin, R. and Chan, C. "A novel unsupervised classification and feature selection method which incorporates ontology information" PLoS One, 3(12):e3869, (2008).

Li, Z.; Srivastava, S.; Yang, X.; Mittal, S.; Norton, P.; Resau, J.; Haab, B.; Chan, C., “A Hierarchical Approach to Identify Pathways that Confer Cytotoxicity in HepG2 Cells from Metabolic and Gene Expression Profiles”, BMC Systems Biology, May 11;1(1):21, (2007).

Kidambi, S.; Sheng, L.; Lee, I; and Chan, C., "Selective Adhesion of Primary Cells in Protein-Free Polyelectrolyte Multilayer Films- Templates for Patterned Cell Co-cultures", Macromolecular Bioscience, 7(3), 344 - 353, (2007).

Srivastava, S.; Chan, C. “Hydrogen peroxide and hydroxyl radical mediate palmitate-induced cytotoxicity to hepatoma cells: relation to MPT," Free Radical Research, 41(1),38-49, (2007).

Li, Z.; Srivastava, S.; Mittal, S.; Yang, X.; Sheng, L.; and Chan, C. “A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathways”, BMC Bioinformatics June 14;8(101):1-17, (2007).

Kidambi, S.; Udpa, N.; Schroeder, S.A.; Findlan, R.; Lee, I.; Chan, C. “Cell Adhesion on Polyelectrolyte Multilayer Coated Polydimethylsiloxane Surfaces with Varying Topographies," Tissue Engineering 13, 2105-2117, (2007).

Patil, S.; Melrose, J.; and Chan, C. “Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons”, European Journal of Neuroscience 26(8):2131-2141, (2007).

Srivastava, S.; Li, Z.; Yang, X.; Yedwabnick, M., Shaw, S.; and Chan, C. “Identification of genes that regulate multiple cellular processes/ responses in the context of lipotoxicity in hepatoma cells” BMC Genomics 8:364, (2007).

Kidambi, S.; Sheng, L.; Yamushc, M.; Tonerc, T.; Lee, I.; Chan, C.* "Patterned Co-culture of Primary Hepatocytes and Fibroblasts using Polyelectrolyte Multilayer Templates," Macromolecular Bioscience 7(3), 344 - 353, (2007).

Patil, S.; Sheng, L.; Masserang, A.; Chan, C. “Palmitic acid-induced BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons,” Neuroscience Letters, 406, 55–59, (2006).

Li, Z., Shaw, S. M., Yedwabnick, M. J., and Chan, C., “Using a state-space model with hidden variables to infer transcription factor activities,” Bioinformatics, 22(6), 747–754, (2006).

Patil, S.; Chan, C. “Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons,” Neuroscience Letters, 384(3), 288-293 (2005).

Kidambi, S.; Lee, I.; Chan, C. "Controlling Primary Hepatocyte Adhesion and Spreading on Protein Free Polyelectrolyte Multilayer Films," Journal of the American Chemical Society 126 (50), 16286 -16287 (2004).

Kidambi, S.; Chan, C.; Lee, I. "Selective Depositions on Polyelectrolyte Multilayers: Self-Assembled Monolayers of m-dPEG Acid as Molecular Templates," Journal of the American Chemical Society 126, 4697-4703 (2004).

Hwang, D. H.; Stephanopoulos, G.; Chan, C. “Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function,” Bioinformatics 20, 487-499, (2004).

Li, Z.; Chan, C. “Inferring pathways and networks with a Bayesian framework,” FASEB J 18(6), 746-748, (2004).

Li, Z.; Chan, C. “Integrating gene expression and metabolic profiles,” Journal Biological Chemistry 279, 27124-27137, (2004).

Li, Z.; Yarmush, M. L.; Chan, C. “Insulin concentration during pre-conditioning mediates the regulation of urea synthesis in primary rat hepatocytes during exposure to amino acid supplemented plasma,” Tissue Engineering 10(11), 1737-1746, (2004).

Chan, C.; Berthiaume, F.; Dwarakanath, B.; Tilles, A. W.; Toner, M.; Yarmush, M. L. “Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies,” Liver Transplantation 10(11), 1331-1342, (2004).

Li, Z.; Chan, C. “Extracting novel information from gene expression data,” Trends in Biotechnology 22, 381-383, (2004).

Chan, C.; Berthiaume, F.; Lee, K.; Yarmush, M.L. "Metabolic Flux Analysis of Cultured Hepatocytes Exposed to Plasma", Biotechnology and Bioengineering 81, 33-49, (2003).

Chan, C.; Hwang, D. H.; Stephanopoulos, G. N.; Yarmush, M. L.; Stephanopoulos, G. "Application of Multivariate Analysis to Optimize Function of Cultured Hepatocytes”, Biotechnology Progress 19, 580-598, (2003).

Chan, C.; Berthiaume, F.; Lee, K.; Yarmush, M. L.; "Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma", Metabolic Engineering 5, 1-15, (2003).

Hwang, D.H.; Stephanopoulos, G.; Chan, C. "Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function", Bioinformatics, (2003).

Chan, C.; Berthiaume, F.; Washuzu, J.; Toner, M.; Yarmush, M. L. "Metabolic Pre-Conditioning of Cultured Cells in Physiological Levels of Insulin: Generating Resistance to the Lipid Accumulating Effects of Plasma in Hepatocytes", Biotechnology and Bioengineering 78, 753-760, (2002).

Washizu, J.; Berthiaume, F.; Chan, C.; Tompkins, R. G.; Toner, M.; Yarmush, M. L. "Optimization of Rat Hepatocyte Culture in Citrated Human Plasma", J. of Surgical Res. 93, 237-246, (2000).

Washizu, J.; Chan, C.; Berthiaume, F.; Tompkins, R. G.; Toner, M.; Yarmush, M. L. "Amino Acid Supplementation Improves Cell-Specific Functions of the Rat Hepatocytes Exposed to Human Plasma", Tissue Eng. 6, 497-504.(2000).

Heng, L.; Chan, C.; Churchill, S. W. "Essentially Exact Characteristics of Turbulent Convection in a Round Tube", Chem. Eng. J. 71, 163-173, (1998).

Brown, M.; Chan, C.; Targett, M.; Holtzmuller, M.; Churchill, S. W. "Combustion of Ethane with Small Concentrations of Methyl Chloride in a Refractory Tube Burner", Comb. Sci. and Tech., 115: 207-227, (1996).

Churchill, S. W.; Chan, C. "Turbulent Flow in Channels in Terms of Local Turbulent Shear Stress and Normal Stresses", AIChE J. 41:2513-2521, (1995).

Churchill, S. W.; Chan, C. "Theoretically Based Correlating Equations for the Local Characteristics of Fully Turbulent Flow in Round Tubes and between Parallel Plates", I&EC Res. 34, 1332-1341, (1995).

Books, Chapters, Monographs

Srivastava, S.; Li, Z.; Chan, C. “Identification of gene-networks associated with cell-death in lipotoxicity”, in Methods in Molecular Biology: Caspase Regulation, ed. Jeffrey Varner, Humana Press Inc., Totowa, NJ, in press, (2010).

Liu, C.; Pyne, R.; Baek, S.; Sakamoto, J.; Tuszynski, M. H.; Chan, C. “Axonal regeneration and myelination: Applicability of the Layer-by-Layer technology”, in Layer-by-Layer Films for Biomedical Applications, eds. Picart, C., Caruso, F., and Voegel, J.C., Wiley-VCH, In press, (2014).

Dalkic, E.; Chan, C. “Biomedical and Clinical Networks of Cancer”, Network Topologies: Types, Performance Impact and Advantages/Disadvantages, Nova Publishers, Chapter 5, p. 131-140, (2013).

Malefyt, A.; Angart, P.; Chan, C.; Walton, S.P. "siRNA Therapeutic Design: Tools and Challenges" In Regulatory RNAs, Part 3; Springer, Eds., 475-503, (2012).

Wang, X.; Geekiyanage, H.; Chan, C. “Network-based Information Synergy Analysis for Alzheimer Disease,” In Statistical and Machine Learning Approaches for Network Analysis; Dehmer, M.; Basak, S., Eds., John Wiley & Sons, Inc., 245-259, (2012).

Nath, A.; Chan, C. “Relevance of Network Hierarchy in Cancer Drug-Target Selection,” In Systems Biology in Cancer Research and Drug Discovery; Azmi, A., Eds., Springer Science + Business Media Dordrecht, 339-362, (2012).

Yang, X.; Wang, X.; Wu, M., Dalkic, E.; and Chan, C. “Construction of the gene network by synergy analysis of the genes related to palmitate-induced cytotoxicity”, Methods in Bioengineering in Systems Analysis of Biological Networks, eds. Arul Jayaraman & Juergen Hahn, Artech House Publishers, Chapter 5, p. 75 – 93, (2009).

Chan, C., Li, Z., and Srivastava, S., “Integration of Micro-Array and Metabolic Data”, Mathematical Modeling in Experimental Nutrition, Chapter 5, p. 82-96, (2007).

Patil, S.; Li, Z.; Chan, C. “Approaches to Optimizing Cellular Function of Engineered Tissue: Cellular to Tissue Informatics,” In Advances in Biochemical Engineering/Biotechnology, volume 102, Lee, K.; Kaplan, D., Eds., Springer: UK, volume 102, p. 139-159, (2006).

Berthiaume, F.; Tilles, A. W.; Toner, M.; Yarmush, M. L.; Chan, C. “Hepatic Tissue Engineering for Adjunct and Temporary Liver Support,” In Tissue Engineering and Artificial Organs, Joseph D. Bronzino, Ed., Taylor and Francis, Chapter 59, p. 1-19, (2006).

Berthiaume, F.; Chan, C.; Yarmush, M. L. “Liver, Bio-artificial” In Encyclopedia of Biomaterials and Biomedical Engineering, G. Wnek; G. Bowlin, Eds.; Marcel Dekker Inc.: New York, Vol. 1, 899-909, (2004).


Li, Z.; and Chan, C. “Systems biology for identifying liver toxicity pathways”, BMC Proceedings, 3(Suppl 2):S2, (10 March 2009).

Chan, C.; Wang, X. Review of Systems Biological Approaches in Infectious Diseases, edited by Helen I. Boshoff and Clifton E. Barry, III, (2009) ChemMedChem, 4, 1–3.

Wang, X.; Wu, M.; Dalkic, E.; Chan, C. “Gene-module level analysis: Identification to Networks and Dynamics”, Current Opinion in Biotechnology, 19, 482–491, (2008).

Wang, X.; Wu, M.; Li, Z.; Chan, C. “Short time-series microarray analysis: methods and challenges”, BMC Systems Biology, 2:58, (2008).

Walton, S. P.; Li, Z.; Chan, C. "Biological network analyses: computational genomics and systems approaches," Molecular Simulation 32(3-4), 203-209, (2006).

Li, Z.; Chan, C. “Extracting novel information from gene expression data,” Trends in Biotechnology 22, 381-383, (2004).

Chan, C.; Berthiaume, F.; Dwarakanath, B.; Tilles, A. W.; Toner, M.; Yarmush, M. L. “Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies”, Liver Transplantation 10(11), 1331-1342, (2004).

Conference Proceedings

Afridi, J.; Liu, C.; Baek, S.; Chan, C.; Liu, X. “Image Segmentation of Mesenchymal Stem Cells in Diverse Culturing Conditions”, WACV 2014: IEEE Winter Conference on Applications of Computer Vision Steamboat Springs CO, (2014).

Liu, C.; Baek, S.; Chan, C. "The Complementary Effect of Mechanical and Chemical Stimuli on the Neural Differentiation of Mesenchymal Stem Cells," ASME Summer Bioengineering Conference, (2012).

Wu, M., Yang, X., and Chan, C., “A dynamic analysis of insulin signaling and its feedback mechanisms: A discrete modeling approach”, RECOMB Regulatory Genomics and Systems Biology, (2009).

Zhou, Y.; Li, Z.; Yang, X.; Zhang, L.; Srivastava, S.; Jin, R.; and Chan, C. “Using Knowledge Driven Matrix Factorization to Reconstruct Modular Gene Regulatory Network”, the Twenty-Third AAAI Conference on Artificial Intelligence (AAAI-08), (2008).

Kidambi, S.; Lee, I.; Chan, C. “Aptamer incorporated polyelectrolyte multilayer films targeting influenza virus's hemagglutinin binding region,” Polymeric Materials: Science and Engineering 97, 246-247, (2007).

Jin, R.; Si, L.; Srivastava, S.; Li, Z.; Chan, C. “A Knowledge Driven Regression Model for Gene Expression and Microarray Analysis,” EMBC Conference Proceedings, (2006).

Kidambi, S.; Lee, I.; Chan, C. "Salt Tunable m-dPEG Acid Patterns on Polyelectrolyte Multilayers – Templates for Directed Deposition of Macromolecules," Polymer Preprints 47(1), 41-42, (2006).

Li, Z.; Srivastava, S.; and Chan, C. “Integrating Gene Expression and Metabolic Profiles to Infer Pathways and Networks that Confer Palmitate Induced Cytotoxicity in HEPG2 Cells,” ASME Summer Bioengineering Conference Proceedings, (2005).

Kidambi, S.; Lee, I. Chan, C., "Polyelectrolyte Multilayer as Bioactive Surface for Cell Adhesion," Polymer Preprints 46(2), 1271-1272, (2005)

Kidambi, S.; Lee, I.; Chan, C. "Engineering Polyelectrolyte Multilayer (PEM) Surfaces to Create Cell Resistant and Adhesive Surfaces" Polymer Preprints 45(1), 88-89, (2004).

Kidambi, S.; Lee, I.; Chan, C. Selective Primary Hepatocyte Adhesion on Polyelectrolyte Multilayer: Template for Patterned Cell Co-Culture. In AIChE Nanotechnology Proceedings (2004).

Chan, C.; Li, Z. “Inferring the Hepatic Network from Experimental Measurements using Bayesian Network Analysis”, ASME Summer Bioengineering Conference Proceedings, (2003).

Chan C., Washizu, J., Berthiaume F., Toner, M., and Yarmush, M. L., “Application of Metabolic Engineering to Cellular Processes of the Liver: As Use in the Development of the Bioartificial Liver”, ASME Summer Bioengineering Conference Proceedings 50, 357-8, (2001).

Chan, C.; Tannenbaum, P. "1997 Inter-Society Color Council Annual Meeting and the Color & Appearance Division of the Society of Plastics Engineers", Color Research and Application, 23, (1998).

Other Works

Huebner, M.; Kroos, L.; Chan, C.; Sun, F.; and Cheng, T. “Biological Networks: Design and Dynamics at Different Levels,” Department of Statistics and Probability, Technical Report MSU RM639, (2005).

Jin, R., Si, L., Chan, C., “Improve the Linear Regression Model in Bioinformatics Using Text Mining”, Technical Report (MSU-CSE-06-9) of Computer Science and Engineering Dept. of Michigan State University (2006).